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The first gene therapy in the U.S., approved last month to treat a rare, inherited form of blindness, now has a price tag: $850,000.

That makes the treatment, called Luxturna and made by Spark Therapeutics, the most expensive medicine sold in the U.S., ranked by sticker price.

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But Spark CEO Jeff Marrazzo says Luxturna’s ability to restore vision in a small number of people with a defective gene justifies the high cost, particularly because the gene therapy is only injected one time in each eye for a long-term benefit. Many investors expected Spark to charge $1 million or more for Luxturna, so the actual price will be considered a bargain by some.

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